Crumbling Genome: The Impact of Deleterious Mutations on Humans
| Author | : | |
| Rating | : | 4.54 (549 Votes) |
| Asin | : | 1118952111 |
| Format Type | : | paperback |
| Number of Pages | : | 296 Pages |
| Publish Date | : | 2015-10-09 |
| Language | : | English |
DESCRIPTION:
Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre?existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them.Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the cu
As of now, we possess no means of reducing the rate at which mutations appear spontaneously. From the Back CoverA thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeingDespite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Milder, but still substantial, negative effects
Alexey S. His research interests include evolution of sex and genetic recombination, properties of spontaneous deleterious mutations and of selection against them, and dynamics of genetic variation in natural and artificial populations. . Kondrashov, PhD is Professor of Ecology and Evolutionary Biology at the University of Michigan, Ann Arbor